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FDA approval in children ages 6 to 11.

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Discontinue cyclosporine at least 24 h before the first dose of tacrolimus.

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Twenty-five patients were recruited, of whom three patients could not withstand the first washout period without using steroid eye drops, and were consequently excluded.

Erythrocytosis (too many red blood cells) may also occur because some of these renal cancers produce a hormone (erythropoietin) that can increase red blood cell production by the bone marrow.

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Effect of Everolimus on Left Ventricular Hypertrophy of De Novo Kidney Transplant Recipients.

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This transport system can also be saturated if the plasma concentrations of the drug are high.

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During the baseline (BL) SBP measurements, both groups were fed the NS diet.

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Previously he worked for six years as a Lecturer in Medicine at the former Westminster Hospital before being appointed Consultant Nephrologist and Physician at St Helier Hospital in 1982.

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The calcium ions then bind to the molecule calmodulin resulting in a complex that activates calcineurin.

These authors contributed equally to this work.

However, in vitro studies have shown that when compared to cyclosporine, tacrolimus exhibits 10-100 times greater immunosuppressive activity.

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Conversion from cyclosporine to FK506 for salvage of immunocompromised pediatric liver allografts.

Further controlled trials are needed to establish safety and efficacy.

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Recently discovered biomarkers may provide valuable new approaches to monitoring immunosuppressive drug therapy in organ transplant recipients--with the potential for individualized therapy to reduce organ rejection and minimize side effects, according to a special article in the April issue of Therapeutic Drug Monitoring, official journal of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

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In addition to being nephrotoxic, calcineurin inhibitors contribute to cardiovascular disease by inducing post-transplantation hypertension, diabetes, and dyslipidemia.

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Critically ill patients with acute liver failure who are likely to die within a week are categorized as status 1 patients and are given highest priority for liver transplantation.

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Seven out of the 10 newborns presented no clinical evidences of malformations or other signs of drug-related toxicity (except for two diagnosis of small for gestational age).

The Use of Mesenchymal Stromal Cells for Treating Renal Injury and Promoting Allograft Survival after Renal Transplantation.

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Chronic graft-versus-host disease (GVHD) occurs in approximately 60 -80% of long-term survivors of allogeneic hematopoietic cell transplant (HCT).

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MTX plasma monitoring is used to reduce the incidence of severe toxicity.

The effect of rituximab dose on infectious complications in ABO-incompatible kidney transplantation.

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Cyclosporine and tacrolimus (FK-506) were originally introduced as immunosuppressive agents for allograft transplantation due to their inhibitory effect on calcineurin, a key signal transduction molecule activating T lymphocytes.

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Division of Transplantation, Department of Nephrology, University of Cincinnati, 231 Albert Sabin Way, ML 585, Medical Sciences Building, Room G163, Cincinnati, OH 45267.